Ike is a main protagonist in Super Smash Bros. Crossover from Seasons 4-19, and reappears after a long absence in Season 22. Ike is recruited by Mario and Princess Peach to be a part of their team for the Neo Smash Champion Tourney, which Ike accepts, as he has acquired a few new tricks. During the first match of the tourney, Ike is pitted against Falco Lombardi due to Wolf O'Donnell altering the matchups, where he reveals he has acquired an Ascent Mode during the time skip. Ike and Mario later help Sonic the Hedgehog during his fight with Meta Knight.
Ike's regular appearance is based off his Brawl appearance. In Ascent Mode, Ike uses his blue palette swap.