Kisame Hoshigaki is a member of the Akatsuki and a major antagonist during Season 20. He was originally partnered with Itachi Uchiha, but after Itachi left the organization, he was partnered with Deidara and Sasori (making the only 3 man Akatsuki team). Kisame is seen watching Piccolo's fight with Nagato and later helps Tobi leave the Hidden Cloud Village after failing to capture Killer B. Kisame later goes with Deidara and Sasori to Smash City in order to capture the last two jinchuriki (Naruto Uzumaki and Killer B), but notices black flames clashing with red flames, which is Itachi fighting against Sasuke Uchiha. After the battle, Kisame betrays Tobu since he lied to Sasuke despite telling Kisame he would end the world of lies. Kisame is unfortunately killed by Yami Bakura, and is then reanimated by Yami Zelda. Kisame is revived in Season 22 due to the rift caused by the improper ressurection of The Offspring of Zorc.
Kisame wears the Akatsuki uniform. In addition, he carries a sword known as Samehada with him.
Kisame is quite sadistic, as he was laughing when Nagato massacred Piccolo. Kisame was very loyal to Tobi until he learned that Madara was untrustworthy. Unlike the rest of the Akatsuki, Kisame bears no hostility towards Itachi after his betrayal.