Mega Man is a major protagonist in Super Smash Bros. Crossover starting with Season 21. He was invited to compete in Smash by Master Hand and Crazy Hand, but he arrived early, though this just gave him the chance to battle earlier. Mega Man eventually becomes a part of the central cast in Season 21, where he is kidnapped by the villains. Mega Man later escapes with the other heroes by outsmarting The Dark Surfer. Mega Man then assists Sonic the Hedgehog in fighting Dr. Eggman and Dr. Wily before they are forced to retreat. After the events of the first arc, Mega Man moves into Smash City. In Season 27, Mega Man assists the Heroes of Legend in their search for Metal Mario, and even participates in the struggle against him.
Mega Man's appearance is based off his modern appearance.
- Mega Man is the first character other than Crash Bandicoot to become a main character in a season other than Season 21.