Professor Xavier is the founder of the Xavier Institute and teacher of the X-Men. From Season 1 to Season 22, Professor Xavier was comatose (like in Wolverine & the X-Men) and would not awaken for 20 years (2 years had passed by Season 23). However, in Season 23, Xavier awakens from his coma for unknown reasons, but decides to help the heroes in the war against Wiseman regardless of the circumstances.
- Professor Xavier is usually referred to Professor X or simply Xavier.
- Professor Xavier is the last X-Man to make his debut in Super Smash Bros. Crossover.