Thanos is a new character in Super Smash Bros. Crossover and a major antagonist in Season 22. Thanos is invited to the Smash Bros. Galaxy by The Dark Surfer, who asks him to join the League of Villains. Thanos is then confronted by Uka Uka, who requests to work with Nebula, which Thanos happily allows. Thanos then uses his Infinity Gauntlet to read The Dark Surfer's mind to learn what he is up against, and is startled to find that one of his new foes is a child (Gohan). Thanos then attacks the heroes after they leave the Vestal Destroyer at the same time as Wiseman.
- Thanos' battle theme is the same as Infinity Titanium Mecha Sonic's.