Zombie Thing is a major antagonist in Super Smash Bros. Crossover starting with Season 16. Zombie Thing is one of the few zombies that are still loyal to Zombie Reed. Zombie Thing is among the few zombies that invaded Earth after Samus Aran went insane. Zombie Thing and Zombie Torch fought Jaden Yuki during the heroes' battle with the Squadron Supreme zombies. Zombie Thing later looks on in horror as Samus betrays and murders Zombie Sue. In Season 18, Zombie Thing is part of Zombie Reed's team that invades Earth again, along with Bowser, Thrax, Zombie Torch, and Zombie Reed himself. Zombie Thing later moves to Pandemonium to start a new life. In Season 29, Zombie Thing is an antagonist again, and assists his teammates in killing Zombie Iron Man before retreating with Zombie Reed. Zombie Thing is later killed by Colonel America after Zombie Reed's ridicule of Zombie Spider-Man causes Colonel America to snap. Zombie Thing is later fully ressurected by Coredegon, along with the rest of the zombie Fantastic Four (excluding Zombie Reed) and Fawful. Zombie Thing is later killed by Mechtavius Destroyer while buying time for the heroes and villains to escape.
- Zombie Thing is the only member of the zombie Fantastic Four that wasn't killed by Zombie Iron Man during The Grand Finale.